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KMID : 1143420200130261866
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Public Health Weekly Report
2020 Volume.13 No. 26 p.1866 ~ p.1878
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Pathogen surveillance of Enterovirus infections in Korea, 2019
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Yoon Young-Sil
Kang Hae-Ji
Lee Young-Pyo
Choi Woo-Young
Han Myung-Guk
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Abstract
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Enterovirus (EV) are known human pathogens and have been associated with various clinical syndromes from mild
manifestations such as hand, foot and mouth disease (HFMD), herpangina, respiratory illness to severe syndromes
aseptic meningitis, encephalitis, myocarditis, acute flaccid paralysis, acute flaccid myelitis, and sepsis.
We analyzed suspected patients with EV infections in Korea in 2019. A total of 1,849 clinical specimens from patients was
tested using real-time reverse transcription polymerase chain reaction (Real-time RT-PCR) and conventional RT-PCR targeting the 5’ untranslated region and VP1 gene of EV, respectively. Among them, 688 cases (37.2%) were detected to be positive for EV infections by either real-time RT-PCR or conventional RT-PCR, or both. The most frequent EV type was EV-A71 (23.1%, 159/688), followed by echovirus 30 (22.2%, 153/688) and coxsackievirus-A6 (12.9%, 89/688) in laboratory-confirmed cases. The detection rate of EV based on the clinical manifestations was 79.0% (215/272) for HFMD, 50.7% (37/73) for herpangina and 35.5% (258/727) for aseptic meningitis or encephalitis. These surveillance data provide information about recent EV infections in Korea at a national level and may encourage progress toward prevention of these infections.
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KEYWORD
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Enterovirus, Enterovirus Infections, Hand, Foot and Mouth Disease, Aseptic Meningitis, Encephalitis, Surveillance data
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